O'Farrell A M, Rex D E, Muthialu A, Pouratian N, Wong G K, Cannestra A F, Chen J W, Toga A W
Division of Brain Mapping, University of California, Los Angeles 90024-1769, USA.
Neuroreport. 2000 Jul 14;11(10):2121-5. doi: 10.1097/00001756-200007140-00013.
Cortical spreading depression (CSD) was imaged in vivo in a rodent model with optical intrinsic signals (OIS). This is the first study to identify a triphasic OIS response and to characterize the rate and timing of the response. The initial OIS phase had a highly uniform wavefront, which spread at a rate characteristic of CSD, 3.5 mm/min. Later phases were more diffuse and inhomogeneous. Blood volume changes, measured with intravascular fluorescent dye, correlated in time and location with the later phases of OIS response. This suggests that the inhomogeneity of the late OIS response may be due to complex residual hemodynamic contributions, as opposed to underlying cortical circuitry.
在啮齿动物模型中，利用光学内在信号（OIS）对皮质扩散性抑制（CSD）进行了活体成像。这是第一项识别出三相OIS反应并描述该反应速率和时间特征的研究。OIS的初始阶段具有高度均匀的波前，其以CSD特有的速率（3.5毫米/分钟）传播。后期阶段则更为弥散且不均匀。用血管内荧光染料测量的血容量变化在时间和位置上与OIS反应的后期阶段相关。这表明OIS反应后期的不均匀性可能是由于复杂的残余血流动力学作用，而非潜在的皮质神经回路所致。
