Maillard L, Ishii K, Bushara K, Waldvogel D, Schulman A E, Hallett M
Human Motor Control Section, Medical Neurology Branch, NINDS, National Institutes of Health, Bethesda, Maryland 20892-1428, USA.
Neurology. 2000 Aug 8;55(3):377-83. doi: 10.1212/wnl.55.3.377.
To noninvasively investigate the somatotopy of the basal ganglia in humans.
Functional MRI, 1.5-T, was performed on six normal right-handed volunteers during simple acoustically paced motor tasks involving the right hand, foot, and face.
In a single-subject analysis, statistical parametric maps showed overlapping activation extending along the anteroposterior extent of the left lentiform nucleus (LLN) for the hand, foot, and face representations. Within the LLN, the centers of gravity of each body part, reflecting both the extent and gradient of activation, were all located in the retrocommissural portion of the putamen. Their spatial relationship followed a similar pattern across subjects-face was medial to toes and fingers, toes were dorsal and rostral to fingers.
The somatotopic organization of hand, face, and foot representation in the human lentiform nucleus suggests a triangular pattern, rather than the linear pattern seen in primate studies. The overlap observed between the distinct body parts differs from the cortical sensorimotor representation, indicating a different organizational concept of the basal ganglia.
以非侵入性方式研究人类基底神经节的躯体定位。
对六名右利手正常志愿者进行1.5-T功能磁共振成像，实验采用简单的声音节奏性运动任务，涉及右手、右脚和面部。
在单受试者分析中，统计参数图显示，沿着左侧豆状核（LLN）的前后范围，手部、足部和面部表征的激活区域相互重叠。在LLN内，每个身体部位的重心反映了激活的范围和梯度，均位于壳核的连合后部分。它们的空间关系在不同受试者之间遵循相似模式——面部位于脚趾和手指的内侧，脚趾位于手指的背侧和嘴侧。
人类豆状核中手部、面部和足部表征的躯体定位组织呈现出三角形模式，而非在灵长类动物研究中所见的线性模式。不同身体部位之间观察到的重叠与皮质感觉运动表征不同，表明基底神经节有不同的组织概念。
