HLA组织相容性抗原、ABO血型及Rh抗原在酒精性肝病中的分布
Distribution of HLA histocompatibility antigens, ABO blood groups and Rh antigens in alcoholic liver disease.
作者信息
Meléndez M, Vargas-Tank L, Fuentes C, Armas-Merino R, Castillo D, Wolff C, Wegmann M E, Soto J
出版信息
Gut. 1979 Apr;20(4):288-90. doi: 10.1136/gut.20.4.288.
Abstract
The distribution of 16 antigens of the HLA-A and 15 antigens of the HLA-B series of HLA system, the blood groups ABO, and Rh antigens were studied in 40 alcoholics with cirrhosis, 18 alcoholics without cirrhosis, and in normal control subjects. The group of alcoholics with cirrhosis showed a significantly high frequency of HLA-B13 (corrected P less than 0.01) when compared with normal subjects, while the frequency of HLA-B13 was similar to normal in alcoholics without cirrhosis. On the basis of these findings, its seems that the carriers of HLA-B13 are more susceptible to liver damage caused by alcohol. Both groups of alcoholics and the normal controls had a similar distribution of ABO blood groups and Rh antigens.
摘要
对40例肝硬化酗酒者、18例无肝硬化酗酒者及正常对照者研究了HLA系统中HLA - A系列的16种抗原、HLA - B系列的15种抗原、ABO血型及Rh抗原的分布情况。与正常受试者相比，肝硬化酗酒组中HLA - B13的频率显著较高（校正P小于0.01），而无肝硬化酗酒者中HLA - B13的频率与正常者相似。基于这些发现，似乎HLA - B13携带者更容易受到酒精所致的肝损伤。酗酒者组和正常对照组的ABO血型及Rh抗原分布相似。
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