人类白细胞抗原（HLA）抗原在酒精性肝病的发展过程中重要吗？
Are HLA antigens important in the development of alcohol-induced liver disease?
作者信息
Faizallah R, Woodrow J C, Krasner N K, Walker R J, Morris A I
出版信息
Br Med J (Clin Res Ed). 1982 Aug 21;285(6341):533-4. doi: 10.1136/bmj.285.6341.533.
Abstract
The prevalences of 10 HLA-A and 16 HLA-B antigens were determined in 50 patients with alcoholic cirrhosis and 120 alcoholic patients without cirrhosis and compared with those in a control group of 550 healthy subjects from the same geographical area. B40 was absent in the patients with cirrhosis but was found in 18 (15%) of the patients without cirrhosis (p = 0.0087). No other association was noted. It is concluded that there is no good evidence to date of an association between HLA antigen state and susceptibility to alcohol-induced cirrhosis.
摘要
在50例酒精性肝硬化患者和120例无肝硬化的酒精性患者中测定了10种HLA - A和16种HLA - B抗原的流行率，并与来自同一地理区域的550名健康受试者组成的对照组进行比较。肝硬化患者中不存在B40，但在无肝硬化的患者中有18例（15%）发现有B40（p = 0.0087）。未发现其他关联。结论是，迄今为止，没有充分证据表明HLA抗原状态与酒精性肝硬化易感性之间存在关联。
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