Morgan M Y, Ross M G, Ng C M, Adams D M, Thomas H C, Sherlock S
J Clin Pathol. 1980 May;33(5):488-92. doi: 10.1136/jcp.33.5.488.
Ninety-two British, caucasian, alcoholic patients with liver disese were grouped on the basis of hepatic histology into fatty change, hepatitis with or without cirrhosis, and cirrhosis alone. Men with alcoholic hepatitis with or without cirrhosis showed an increased incidence of the histocompatibility antigen HLA-B8 (P less than 0.02). Increased measles antibody titres were found in patients without cirrhosis with or without hepatitis and were associated with the B8 phenotype in both sexes. Rubella antibody titres and percentage DNA-binding were raised in patients with cirrhosis and showed no association with the B8 phenotype. Concentrations of IgM and IgA were were raised in patients with stetosis and with hepatitis, while in patients with cirrhosis IgG concentrations were also increased. Low titres of autoantibodies were found in all histological groups. It is possible that the development of hepatitis in response to alcohol abuse may be influenced, at least in men, by a gene linked to the B locus. Otherwise, immune processes associated with alcohol-related liver disease are probably secondary phenomena.
92名患有肝脏疾病的英国白种酗酒患者，根据肝脏组织学被分为脂肪变性、伴有或不伴有肝硬化的肝炎以及单纯肝硬化三组。患有伴有或不伴有肝硬化的酒精性肝炎的男性患者，组织相容性抗原HLA - B8的发生率增加（P小于0.02）。在没有肝硬化且伴有或不伴有肝炎的患者中发现麻疹抗体滴度升高，并且在男女患者中均与B8表型相关。风疹抗体滴度和DNA结合百分比在肝硬化患者中升高，且与B8表型无关。IgM和IgA的浓度在患有脂肪变性和肝炎的患者中升高，而在肝硬化患者中IgG浓度也增加。在所有组织学组中均发现低滴度的自身抗体。对酒精滥用产生的肝炎发展，至少在男性中，可能受到与B位点相关基因的影响。否则，与酒精性肝病相关的免疫过程可能是继发现象。
