Sternlieb I, Bennett B, Scheinberg I H
Ann Intern Med. 1975 May;82(5):673-6. doi: 10.7326/0003-4819-82-5-673.
Fatal pulmonary hemorrhages and rapidly progressive glomerulonephritis occurred in three patients with Wilson's disease (hepatolenticular degeneration) who had been treated with penicillamine for 2 to 31/2 years. Light microscopic studies of the kidneys showed severe glomerulonephritis with crescent formation, and the lungs showed intraalveolar hemorrhages. Although the clinical and pathologic abnormalities were those of Goodpasture's syndrome, immunofluorescence microscopic studies in the one case tested showed an interrupted, rather than linear, fluorescence pattern.
三名患有威尔逊氏病（肝豆状核变性）的患者在接受青霉胺治疗2至3.5年后出现致命性肺出血和快速进展性肾小球肾炎。肾脏的光镜检查显示严重的肾小球肾炎伴新月体形成，肺部显示肺泡内出血。尽管临床和病理异常表现为古德帕斯彻综合征，但在检测的一例病例中，免疫荧光显微镜检查显示为间断性而非线性荧光模式。
