Lekcharoensuk C, Lulich J P, Osborne C A, Koehler L A, Urlich L K, Carpenter K A, Swanson L L
Minnesota Urolith Center, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA.
J Am Vet Med Assoc. 2000 Aug 15;217(4):520-5. doi: 10.2460/javma.2000.217.520.
To determine whether breed, age, sex, or reproductive status (i.e., neutered versus sexually intact) was associated with the apparent increase in prevalence of calcium oxalate (CaOx) uroliths and the decrease in prevalence of magnesium ammonium phosphate (MAP) uroliths in cats over time.
Case-control study.
Case cats consisted of cats with CaOx (n = 7,895) or MAP (7,334) uroliths evaluated at the Minnesota Urolith Center between 1981 and 1997. Control cats consisted of cats without urinary tract disease admitted to veterinary teaching hospitals in the United States and Canada during the same period (150,482).
Univariate and multivariate logistic regression were performed.
British Shorthair, Exotic Shorthair, Foreign Shorthair, Havana Brown, Himalayan, Persian, Ragdoll, and Scottish Fold cats had an increased risk of developing CaOx uroliths, as did male cats and neutered cats. Chartreux, domestic shorthair, Foreign Shorthair, Himalayan, Oriental Shorthair, and Ragdoll cats had an increased risk of developing MAP uroliths, as did female cats and neutered cats. Cats with CaOx uroliths were significantly older than cats with MAP uroliths.
Results suggest that changes in breed, age, sex, or reproductive status did not contribute to the apparent reciprocal relationship between prevalences of CaOx and MAP uroliths in cats during a 17-year period. However, cats of particular breeds, ages, sex, and reproductive status had an increased risk of developing CaOx and MAP uroliths.
确定品种、年龄、性别或生殖状态（即绝育与未绝育）是否与猫草酸钙（CaOx）尿石症患病率的明显增加以及磷酸镁铵（MAP）尿石症患病率随时间的下降有关。
病例对照研究。
病例猫包括1981年至1997年间在明尼苏达尿石症中心评估的患有CaOx（n = 7895）或MAP（7334）尿石症的猫。对照猫包括同期在美国和加拿大兽医教学医院收治的无泌尿系统疾病的猫（150482只）。
进行单变量和多变量逻辑回归分析。
英国短毛猫、异国短毛猫、外国短毛猫、哈瓦那棕猫、喜马拉雅猫、波斯猫、布偶猫和苏格兰折耳猫患CaOx尿石症的风险增加，雄性猫和绝育猫也是如此。沙特尔猫、家猫短毛猫、外国短毛猫、喜马拉雅猫、东方短毛猫和布偶猫患MAP尿石症的风险增加，雌性猫和绝育猫也是如此。患有CaOx尿石症的猫比患有MAP尿石症的猫年龄显著更大。
结果表明，在17年期间，品种、年龄、性别或生殖状态的变化并未导致猫CaOx和MAP尿石症患病率之间明显的反向关系。然而，特定品种、年龄、性别和生殖状态的猫患CaOx和MAP尿石症的风险增加。
