Cooper C S, Passerini-Glazel G, Hutcheson J C, Iafrate M, Camuffo C, Milani C, Snyder H M
Division of Pediatric Urology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
J Urol. 2000 Sep;164(3 Pt 2):1097-9; discussion 1099-100. doi: 10.1097/00005392-200009020-00045.
Endoscopic incision was performed as the initial therapy for ureteroceles in children presenting to our institutions between 1985 and 1990. To assess the long-term efficacy of this treatment modality we reevaluated the outcome of these patients.
Parameters reviewed included patient age at surgery, position of the ureterocele, a duplex system, preoperative and postoperative reflux, and the need for additional operations. Statistical analysis consisted of chi-square and Wilcoxon's rank sum tests.
Of the patients 22 had intravesical and 22 had extravesical ureteroceles. Average age at initial surgery was 1.9 +/- 3.7 years with average followup of 7.2 +/- 3.1 years. A second operation was required in 18 cases (41%), which was significantly more likely for an extravesical ureterocele (18% versus 64%, p = 0. 002), a duplex system (p = 0.026) or preoperative reflux (p = 0.02). Second operations included reimplantation in 13 cases, upper pole partial nephrectomy in 7, total nephroureterectomy in 3, bladder neck reconstruction in 3 and lower pole pyeloplasty in 3. The only secondary operations performed for intravesical ureteroceles were reimplantation in 3 cases and upper pole nephrectomy in 1. New onset reflux developed in 14 of 27 patients (52%) postoperatively, including 7 with intravesical and 7 with extravesical ureteroceles. None required a second open operation.
With extended followup the percentage of patients requiring open surgery after endoscopic incision of ureteroceles increased from our original report of 27% to 41% (p = 0.166). Only 18% of cases with an intravesical ureterocele required a subsequent operation compared to 64% with an extravesical ureterocele (p = 0.002). The reduction in size of the obstructed ureter following endoscopic decompression facilitated successful reimplantation. Endoscopic puncture permits definitive treatment in the majority of children by at most a single incision, open operation at the bladder level.
1985年至1990年间,我们对前来本院就诊的儿童输尿管囊肿患者,采用内镜下切开作为初始治疗方法。为评估这种治疗方式的长期疗效,我们对这些患者的治疗结果进行了重新评估。
回顾的参数包括手术时患者年龄、输尿管囊肿位置、重复肾系统、术前和术后反流情况以及是否需要再次手术。统计分析采用卡方检验和威尔科克森秩和检验。
患者中,22例为膀胱内输尿管囊肿,22例为膀胱外输尿管囊肿。初次手术时的平均年龄为1.9±3.7岁,平均随访时间为7.2±3.1年。18例(41%)患者需要再次手术,对于膀胱外输尿管囊肿(18%对64%,p = 0.002)、重复肾系统(p = 0.026)或术前存在反流(p = 0.02)的患者,再次手术的可能性显著更高。再次手术包括13例输尿管再植术、7例上极部分肾切除术、3例全肾输尿管切除术、3例膀胱颈重建术和3例下极肾盂成形术。膀胱内输尿管囊肿仅进行了3例输尿管再植术和1例上极肾切除术作为二次手术。27例患者中有14例(52%)术后出现新发反流,其中膀胱内输尿管囊肿7例,膀胱外输尿管囊肿7例。均无需再次开放手术。
随着随访时间延长,输尿管囊肿内镜下切开术后需要开放手术的患者比例从我们最初报告的27%增加到41%(p = 0.166)。膀胱内输尿管囊肿患者仅18%需要后续手术,而膀胱外输尿管囊肿患者为64%(p = 0.002)。内镜减压后梗阻输尿管尺寸减小,有利于成功进行输尿管再植术。内镜穿刺允许通过最多一次膀胱水平的切开,对大多数儿童进行确定性治疗。