Matsumoto M, Sugiura H, Uehara M
H&B Research Laboratory, Central Research Institute, SUNSTAR Inc., 3-1, Asahi-machi, Takatsu, Osaka 569-1195, Japan.
J Dermatol Sci. 2000 Aug;23(3):178-82. doi: 10.1016/s0923-1811(00)00073-6.
Although it has been well established that the dry skin often seen in patients with atopic dermatitis shows a deranged barrier function, there is no unanimity of opinion as to whether the barrier in normal-appearing skin of patients with the disease is deranged or not. Hence, it remains unclear whether individuals with atopic dermatitis constitution have an intrinsic derangement of skin barrier function or not. To settle this problem, in the present study we examined transepidermal water loss and stratum corneum water content in normal appearing skin of the upper back of 16 patients with completely healed atopic dermatitis who had been free from skin symptoms for 5 years or more, 30 patients with active atopic dermatitis, and 39 healthy subjects. The transepidermal water loss values and the stratum corneum water content values in normal-appearing skin of the completely healed patients were not different from the values in normal controls. These findings indicate that skin barrier function is not disturbed in patients with completely healed atopic dermatitis.
虽然已经充分证实，特应性皮炎患者中常见的干性皮肤表现出屏障功能紊乱，但对于该病患者外观正常的皮肤屏障是否紊乱，尚无一致意见。因此，尚不清楚具有特应性皮炎体质的个体是否存在皮肤屏障功能的内在紊乱。为了解决这个问题，在本研究中，我们检测了16例特应性皮炎已完全治愈且皮肤症状已缓解5年或更长时间的患者、30例活动性特应性皮炎患者以及39名健康受试者上背部外观正常皮肤的经表皮水分流失和角质层含水量。完全治愈患者外观正常皮肤的经表皮水分流失值和角质层含水量值与正常对照组的值没有差异。这些发现表明，特应性皮炎完全治愈的患者皮肤屏障功能未受干扰。
