视神经氧分压：眼压和多佐胺的影响
Optic nerve oxygen tension: effects of intraocular pressure and dorzolamide.
作者信息
la Cour M, Kiilgaard J F, Eysteinsson T, Wiencke A K, Bang K, Dollerup J, Jensen P K, Stefánsson E
机构信息
Eye Department, National University Hospital, University of Copenhagen, Denmark.
出版信息
Br J Ophthalmol. 2000 Sep;84(9):1045-9. doi: 10.1136/bjo.84.9.1045.
AIM
To investigate the influence of acute changes in intraocular pressure on the oxygen tension in the vicinity of the optic nerve head under control conditions and after intravenous administration of 500 mg of the carbonic anhydrase inhibitor dorzolamide.
METHODS
Domestic pigs were used as experimental animals. Oxygen tension was measured by means of a polarographic electrode in the vitreous 0.5 mm anterior to the optic disc. This entity is called the optic nerve oxygen tension. Intraocular pressure was controlled by a hypodermic needle inserted into the anterior chamber and connected to a saline reservoir.
RESULTS
When the intraocular pressure was clamped at 20 cm H2O optic nerve oxygen tension was 20 (5) mm Hg (n=8). Intravenous administration of dorzolamide caused an increase in optic nerve oxygen tension of 43 (8)% (n=6). Both before and after administration of dorzolamide optic nerve oxygen tension was unaffected by changes in intraocular pressure, as long as this pressure remained below 60 cm H2O. At intraocular pressures of 60 cm H(2)O and below, dorzolamide significantly increased optic nerve oxygen tension.
CONCLUSION
Intravenous administration of 500 mg dorzolamide increases the oxygen tension at the optic nerve head during acute increases in intraocular pressure.
目的
研究在对照条件下以及静脉注射500毫克碳酸酐酶抑制剂多佐胺后，眼压急性变化对视神经乳头附近氧分压的影响。
方法
使用家猪作为实验动物。通过极谱电极在视盘前方0.5毫米处的玻璃体内测量氧分压。这个指标被称为视神经氧分压。通过插入前房并连接到盐水储液器的皮下针来控制眼压。
结果
当眼压固定在20厘米水柱时，视神经氧分压为20（5）毫米汞柱（n = 8）。静脉注射多佐胺导致视神经氧分压增加43（8）%（n = 6）。在注射多佐胺前后，只要眼压保持在60厘米水柱以下，视神经氧分压不受眼压变化的影响。在眼压为60厘米水柱及以下时，多佐胺显著增加视神经氧分压。
结论
静脉注射500毫克多佐胺可在眼压急性升高期间增加视神经乳头处的氧分压。
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