Santos R A, Campagnole-Santos M J, Andrade S P
Departamento de Fisiologia e Biofísica, Av. Antonio Carlos, 6627 - Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG Brazil.
Regul Pept. 2000 Jul 28;91(1-3):45-62. doi: 10.1016/s0167-0115(00)00138-5.
The renin-angiotensin system is a major physiological regulator of arterial pressure and hydro-electrolyte balance. Evidence has now been accumulated that in addition to angiotensin (Ang) II other Ang peptides [Ang III, Ang IV and Ang-(1-7)], formed in the limited proteolysis processing of angiotensinogen, are importantly involved in mediating several actions of the RAS. In this article we will review our knowledge of the biological actions of Ang-(1-7) with focus on the puzzling aspects of the mediation of its effects and the interaction Ang-(1-7)-kinins. In addition, we will attempt to summarize the evidence that Ang-(1-7) takes an important part of the mechanisms aimed to counteract the vasoconstrictor and proliferative effects of Ang II.
肾素-血管紧张素系统是动脉血压和水电解质平衡的主要生理调节因子。现已积累的证据表明，除了血管紧张素（Ang）II外，在血管紧张素原的有限蛋白水解过程中形成的其他Ang肽[Ang III、Ang IV和Ang-(1-7)]，在介导肾素-血管紧张素系统的多种作用中也起着重要作用。在本文中，我们将回顾我们对Ang-(1-7)生物学作用的认识，重点关注其作用介导的令人困惑的方面以及Ang-(1-7)与激肽的相互作用。此外，我们将试图总结证据，表明Ang-(1-7)在旨在抵消Ang II的血管收缩和增殖作用的机制中起重要作用。
