Miendje Deyi Y, Goubau P, Bodéus M
Department of Microbiology, Université Catholique de Louvain, Brussels, Belgium.
Eur J Clin Microbiol Infect Dis. 2000 Jul;19(7):557-60. doi: 10.1007/s100960000317.
The diagnosis of acute cytomegalovirus (CMV) infection is frequently based on a positive IgM result. False-positive reactions due to interfering infections may exist. Between August 1998 and May 1999, 62 patients were found to be IgM positive and IgG negative with the Axsym assay (Abbott, Germany). Serological testing for Epstein-Barr virus (EBV) was performed in these patients to detect any cross-reactivity due to acute mononucleosis. Additionally, the results of the CMV Axsym was evaluated in 40 patients with acute EBV infection. The results suggest that the CMV-IgM Axsym assay shows a lack of specificity due to acute EBV infection. Precautions must be taken when CMV-IgM Axsym results are interpreted. It seems necessary to confirm equivocal results with another technique and to take into account other clinical and biological observations.
急性巨细胞病毒（CMV）感染的诊断通常基于IgM结果呈阳性。可能存在因干扰性感染导致的假阳性反应。在1998年8月至1999年5月期间，通过Axsym检测法（德国雅培公司）发现62例患者IgM呈阳性而IgG呈阴性。对这些患者进行了爱泼斯坦-巴尔病毒（EBV）的血清学检测，以检测急性单核细胞增多症引起的任何交叉反应。此外，对40例急性EBV感染患者的CMV Axsym检测结果进行了评估。结果表明，由于急性EBV感染，CMV-IgM Axsym检测法缺乏特异性。在解读CMV-IgM Axsym检测结果时必须采取预防措施。似乎有必要用另一种技术来确认不确定的结果，并考虑其他临床和生物学观察结果。
