Hosbach H A, Kubli E
Mech Ageing Dev. 1979 Apr;10(1-2):141-9. doi: 10.1016/0047-6374(79)90077-0.
Transfer RNA and aminoacyl-tRNA synthetases have been isolated from 5 and 35 day old Drosophila melanogaster males. The isoacceptor pattern of the following tRNAs is not changed irrespective of the source of the tRNA and amino-acylating enzymes: tRNAAla, tRNALeu, tRNAMet, and tRNASer. However, the Q base containing tRNAAsp, tRNAAsN, tRNAHis, and tRNATyr show dramatic changes in their isoacceptor patterns during the aging process. This probably reflects a change in the activity of a tRNA modifying enzyme. These findings are discussed in relation to Strehler's theory of aging and development.
已从5日龄和35日龄的黑腹果蝇雄性个体中分离出了转移核糖核酸（tRNA）和氨酰tRNA合成酶。无论tRNA和氨酰化酶的来源如何，以下tRNA的同功受体模式均未发生变化：丙氨酸tRNA、亮氨酸tRNA、甲硫氨酸tRNA和丝氨酸tRNA。然而，含有Q碱基的天冬氨酸tRNA、天冬酰胺tRNA、组氨酸tRNA和酪氨酸tRNA在衰老过程中其同功受体模式发生了显著变化。这可能反映了一种tRNA修饰酶活性的改变。结合斯特勒的衰老与发育理论对这些发现进行了讨论。
