Quertemont E, Lallemand F, Colombo G, De Witte P
Biologie du Comportement, Université Catholique de Louvain, Place Croix du Sud 1, 1348 Louvain-La-Neuve, Belgium.
Eur Neuropsychopharmacol. 2000 Sep;10(5):377-83. doi: 10.1016/s0924-977x(00)00095-x.
Recent intracerebral microdialysis studies of different rat brain regions have shown that an acute ethanol injection induced a rapid dose-dependent increase in taurine microdialysate content during the first 60-min period. In taurine-supplemented rats, a reduced aversion for high ethanol doses was observed in a place conditioning paradigm, suggesting that taurine may be implicated in the regulation of some adverse effects of ethanol. The present study compares the effects of acute ethanol injections (1.0 and 2.0 g/kg, i.p.) on taurine nucleus accumbens microdialysate content in Sardinian ethanol-preferring (sP) and Sardinian ethanol-non-preferring (sNP) rats. While neither saline nor 1.0 g/kg ethanol injections had significant effect on taurine microdialysate concentration, 2.0 g/kg ethanol administration induced a rapid and significant increase in taurine microdialysate content in both sP and sNP rats. However, this ethanol-induced taurine release was significantly reduced in sP rats by comparison to sNP rats. As taurine is suggested to be released by brain cells to modulate different ethanol adverse effects, this lower taurine responsiveness to ethanol in sP rats by comparison to both sNP and Wistar rats may be a relevant indicator of reduced ethanol aversive effects in such animals and therefore be related to their higher alcohol consumption.
最近对不同大鼠脑区进行的脑内微透析研究表明，急性注射乙醇会在最初60分钟内导致牛磺酸微透析液含量迅速呈剂量依赖性增加。在补充牛磺酸的大鼠中，在位置条件反射范式中观察到对高剂量乙醇的厌恶感降低，这表明牛磺酸可能参与了乙醇某些不良反应的调节。本研究比较了急性注射乙醇（1.0和2.0 g/kg，腹腔注射）对撒丁岛嗜乙醇（sP）和撒丁岛非嗜乙醇（sNP）大鼠伏隔核中牛磺酸微透析液含量的影响。生理盐水注射和1.0 g/kg乙醇注射对牛磺酸微透析液浓度均无显著影响，而2.0 g/kg乙醇给药导致sP和sNP大鼠的牛磺酸微透析液含量迅速且显著增加。然而，与sNP大鼠相比，sP大鼠中这种乙醇诱导的牛磺酸释放显著减少。由于牛磺酸被认为是由脑细胞释放以调节乙醇的不同不良反应，与sNP大鼠和Wistar大鼠相比，sP大鼠对乙醇的牛磺酸反应性较低，这可能是这类动物乙醇厌恶效应降低的一个相关指标，因此与它们较高的酒精消耗量有关。
