Vatn M H, Semb L S, Schrumpf E
Scand J Gastroenterol. 1975;10(1):59-64.
The gastric secretion of IF, acid, and pepsin during basal conditions and stimulation by pentagastrin decreased significantly in 8 unoperated duodenal ulcer patients following administration of atropine. The basal concentrations of acid and pepsin decreased, whereas that of IF remained unchanged. An increase of plasma gastrin concentration from the basal value was observed after injection of atropine alone. The secretions of IF and acid decreased significantly from the pre-operative values after proximal gastric vagotomy in 7 duodenal ulcer patients. The basal IF output decreased by 19.8 per cent and the stimulated output by 41.4 per cent. The basal and stimulated secretions of acid decreased by 50.0 and 44.1 per cent, respectively. It is suggested that the smaller reduction of IF than of acid may be of importance for the vitamin B12 absorption after vagotomy. The decreased secretion of IF was secondary to the reduction of volume both after'medical' and surgical vagotomy.
在8例未经手术的十二指肠溃疡患者中，给予阿托品后，基础状态下以及由五肽胃泌素刺激引起的内因子（IF）、胃酸和胃蛋白酶的分泌显著减少。胃酸和胃蛋白酶的基础浓度降低，而内因子的基础浓度保持不变。单独注射阿托品后，血浆胃泌素浓度从基础值升高。在7例十二指肠溃疡患者行近端胃迷走神经切断术后，内因子和胃酸的分泌较术前值显著减少。基础内因子分泌量减少19.8%，刺激后分泌量减少41.4%。胃酸的基础分泌和刺激分泌分别减少50.0%和44.1%。提示内因子分泌减少幅度小于胃酸分泌减少幅度可能对迷走神经切断术后维生素B12的吸收具有重要意义。无论是“药物性”还是手术性迷走神经切断术后，内因子分泌减少继发于分泌量的减少。
