Luitse S, Franssen R M, Hogenboom R M, Hengeveld W L
Chemotherapy. 1975;21 Suppl 1:136-42. doi: 10.1159/000221900.
A multi-centre general practitioner trial was carried out in the Netherlands during the winter of 1973/1974. This trial was part of a larger pan-European study. There were 13- cases studied in the Netherlands who were only treated with doxycycline, by 17 physicians. All patients included in the trial had an acute infection of either the upper or lower respiratory tract. tthere were 64 females and 66 males. The results were excellent at 100 patients (76.9%) had a very good result, 21 patients (16.2%) had moderate or fair results, and only 7 patients (5.4%) had poor or negative results. Doxycycline was well tolerated as no side-effects were noted in 122 of the patients (93.8%). In the 8 patients who experienced side-effects they were mild and self-limiting.
1973年冬/1974年冬，荷兰开展了一项多中心全科医生试验。该试验是一项规模更大的泛欧研究的一部分。在荷兰，17名医生对130例仅接受强力霉素治疗的病例进行了研究。试验纳入的所有患者均患有上呼吸道或下呼吸道急性感染。其中有64名女性和66名男性。结果非常好，100名患者（76.9%）疗效极佳，21名患者（16.2%）疗效中等或尚可，只有7名患者（5.4%）疗效差或无效。强力霉素耐受性良好，122名患者（93.8%）未出现副作用。在8名出现副作用的患者中，副作用轻微且为自限性。
