Meier J
Chemotherapy. 1975;21 Suppl 1:130-5. doi: 10.1159/000221899.
A total of 256 patients were admitted in Germany into a Pan-European multi centre trial of doxycycline in the treatment of infections of the respiratory tract. The diagnoses showed a preponderance of lower respiratory tract infections compared with other European countries, due largely to the fact that the participating physicians were pulmonary or internal medicine specialists. Doxycycline was given in a dose of 200 mg initially followed by 100 mg daily for 5-10 days (only the occasional patient varied from this regimen). Side-effects were uncommon (2.5-3.5%) and affected only the gastrointestinal tract. Four patients had to change antibiotic therapy, not because of side-effects but because of possible bacterial resistance in these patients. The results were comparable with those from the rest of Europe: 88% of patients had a good or very good response. Nine patients were treated for longer than 14 days and only eight patients did not show improvement.
共有256名德国患者被纳入一项泛欧洲多中心试验，该试验旨在研究多西环素治疗呼吸道感染的效果。与其他欧洲国家相比，诊断结果显示下呼吸道感染占比更大，这主要是因为参与试验的医生均为肺科或内科专家。多西环素的给药剂量为初始200毫克，随后每日100毫克，持续5至10天（只有个别患者未遵循此方案）。副作用并不常见（2.5 - 3.5%），且仅影响胃肠道。有4名患者不得不更换抗生素治疗，并非因为副作用，而是因为这些患者可能存在细菌耐药性。结果与欧洲其他地区相当：88%的患者有良好或非常良好的反应。9名患者接受治疗的时间超过14天，只有8名患者未见改善。
