Herz G, Gfeller J
Chemotherapy. 1975;21 Suppl 1:58-67. doi: 10.1159/000221892.
The effectiveness of and tolerance to doxycycline (Vibramycin, Pfizer) was investigated in a group of 188 children and the radpidity of both subjective and objective improvement was assessed in a second group of 58 children. Doxycycline was found to be very effective. It was possible to analyse the results of treatment in 245 out of the total of 246 patients. Cure was obtained in 168 patients (68.6%) and marked improvement was seen in 59 (24.1%). The overall success rate was thus 92.7%. 18 patients (7.3%) failed to respond; these either had a history of relapsing infections or were infected with resistant organisms. Doxycycline also proved to be rapid in its effect. Rapid subjective improvement was seen in 48 out of 58 patients (84.2%) and rapid objective improvement in 41 patients (70.7%). Tolerance to doxycycline was very good. Treatment had to be interrupted in only one out of 246 patients; there were initial gastrointestinal symptoms in 4 patients. Doxycycline showed itself to be a very suitable antibiotic for use in day-to-day paediatric practice.
对188名儿童使用强力霉素（辉瑞公司的盐酸多西环素）进行疗效和耐受性研究，并在另一组58名儿童中评估主观和客观改善的速度。结果发现强力霉素非常有效。在总共246名患者中，有245名患者的治疗结果可供分析。168名患者（68.6%）治愈，59名患者（24.1%）明显好转。因此，总成功率为92.7%。18名患者（7.3%）治疗无效；这些患者要么有复发性感染病史，要么感染了耐药菌。强力霉素的起效也很快。58名患者中有48名（84.2%）主观症状迅速改善，41名患者（70.7%）客观症状迅速改善。强力霉素的耐受性非常好。246名患者中只有1名患者的治疗不得不中断；4名患者有初始胃肠道症状。强力霉素是日常儿科临床中非常合适的一种抗生素。
