Endo S, Inada K, Yamada Y, Wakabayashi G, Ishikura H, Tanaka T, Sato S
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
J Med. 2000;31(1-2):15-20.
IL-18 levels in the blood of 13 sepsis patients were assessed. The IL-18 values were significantly correlated with their Acute Physiology and Chronic Health Evaluation (APACHE) II scores, and they were a good reflection of the severity of the disease. There was also a strong correlation between the IL-18 values and the patients' inflammatory cytokine levels. The results suggested strong involvement of IL-18 in the pathogenesis of sepsis.
对13名脓毒症患者血液中的白细胞介素-18(IL-18)水平进行了评估。IL-18值与他们的急性生理与慢性健康状况评分系统(APACHE)II评分显著相关,并且是疾病严重程度的良好反映。IL-18值与患者的炎性细胞因子水平之间也存在很强的相关性。结果表明IL-18在脓毒症发病机制中起重要作用。