Riese H, Van Doornen L J, Houtman I L, De Geus E J
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
Health Psychol. 2000 Sep;19(5):429-40. doi: 10.1037//0278-6133.19.5.429.
This study examined the possible effects of job demands, decision latitude, and job-related social support on risk indicators for cardiovascular disease (CVD) in 165 female nurses. Job strain was measured with the Job Content Questionnaire; CVD risk was measured with insulin, total cholesterol, triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), fibrinogen, tissue-type plasminogen activator (tPA) antigen, tPA activity, plasminogen activator inhibitor-1 antigen, and blood pressure. Multivariate analysis of covariance and regression analyses revealed no effects of either job strain or social support on these risk indicators. All risk indicators deteriorated with age and body mass index. Oral contraceptive use improved fibrinolytic potential and increased HDL-C but had adverse effects on TG levels. Results suggest that in healthy young women job strain is not associated with an unfavorable metabolic or fibrinolytic risk profile.
本研究调查了工作要求、决策自由度和工作相关社会支持对165名女护士心血管疾病（CVD）风险指标的可能影响。采用工作内容问卷测量工作压力；采用胰岛素、总胆固醇、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、纤维蛋白原、组织型纤溶酶原激活剂（tPA）抗原、tPA活性、纤溶酶原激活剂抑制剂-1抗原和血压测量CVD风险。多变量协方差分析和回归分析显示，工作压力和社会支持对这些风险指标均无影响。所有风险指标均随年龄和体重指数的增加而恶化。口服避孕药可改善纤溶潜力并提高HDL-C水平，但对TG水平有不良影响。结果表明，在健康年轻女性中，工作压力与不良的代谢或纤溶风险状况无关。
