Breur K, Burgers J M, Cleton F, Hart A A, Somers R, Van Unnik J A, Kroese W F, Van Turnhout J M
Br J Cancer Suppl. 1975 Mar;2:265-9.
The spread of non-Hodgkin's lymphomata was investigated in a group of 323 cases. Differences were sought between 4 histological groups: lymphocytic vs histiocytic lymphomata and diffuse vs follicular types. Histiocytic and follicular types were rare in childhood. Histiocytic lymphomata, compared with lymphocytic ones, were more often confined to sites above the diaphragm. They exhibited a higher rate of loco-regional recurrences within the first 3 months and also of late recurrence after 4 years. Lymphocytic lymphomata of the follicular type more commonly presented with nodal involvement below the diaphragm as primary or secondary site than the diffuse form. Follicular types of lymphoma compared with diffuse types, occurred more frequently in women. They were more seldom seen as primary or secondary sites in extranodal localizations. They had a smaller chance of late disease recurrence and were associated with a longer survival time after first recurrence. The mediastinum often remained clinically uninvolved. With regard to this mediastinal "skip" no differences were found between the histological groups.
对323例非霍奇金淋巴瘤患者的病情扩散情况进行了调查研究。研究了4种组织学类型之间的差异：淋巴细胞性淋巴瘤与组织细胞性淋巴瘤，以及弥漫型与滤泡型。组织细胞型和滤泡型在儿童期较为罕见。与淋巴细胞性淋巴瘤相比，组织细胞性淋巴瘤更常局限于横膈膜以上部位。它们在前3个月内局部区域复发率较高，4年后晚期复发率也较高。滤泡型淋巴细胞性淋巴瘤作为原发或继发部位，累及横膈膜以下淋巴结的情况比弥漫型更为常见。与弥漫型相比，滤泡型淋巴瘤在女性中更为常见。它们作为结外定位的原发或继发部位较少见。它们晚期疾病复发的几率较小，首次复发后生存期较长。纵隔在临床上通常未受累。关于这种纵隔“跳跃”现象，各组织学类型之间未发现差异。
