Bennett M H
Br J Cancer Suppl. 1975 Mar;2:44-52.
A total of 242 cases of non-Hodgkin's lymphoma arising primarily in lymph nodes are reported. Lymph nodes have been classified histologically and the incidence of sclerosis in each group assessed. Two types of fibrosis were found, one composed of fibrous bands from 10 mum to several hundred mum thick within the node and invaded perinodal tissue. The other type was a fine compartmentalizing fibrosis sometimes simulating the pattern of metastatic carcinoma in part of a node, the rest of the node being typical of malignant lymphoma. Both types of fibrosis were present in some nodes. Fibrous bands were present in all histological types, with the exception of the diffuse lymphocytic well differentiated group. Fine compartmentalizing fibrosis was seen only in association with areas of undifferentiated large celled lymphoma. The presence of sclerosis is shown to correlate with a better prognosis when compared with non-sclerosing tymours of similar histological type. That sclerosing lymphomata are more slowly progressive is borne out by the fact that two-thirds of the patients with sclerotic nodes presented with localized disease compared with less than half of the patients whose nodes showed no sclerosis.
本文报告了242例主要发生于淋巴结的非霍奇金淋巴瘤。对淋巴结进行了组织学分类，并评估了每组中硬化的发生率。发现了两种类型的纤维化，一种由淋巴结内10微米至数百微米厚的纤维带组成，并侵犯淋巴结周围组织。另一种类型是细微的分隔性纤维化，有时在部分淋巴结中模拟转移癌的模式，而其余淋巴结则为典型的恶性淋巴瘤。两种类型的纤维化在一些淋巴结中均存在。除弥漫性淋巴细胞高分化组外，所有组织学类型中均可见纤维带。细微的分隔性纤维化仅见于未分化大细胞淋巴瘤区域。与组织学类型相似的非硬化性肿瘤相比，硬化的存在与较好的预后相关。硬化性淋巴瘤进展较慢这一事实表明，三分之二有硬化淋巴结的患者表现为局限性疾病，而淋巴结无硬化的患者中这一比例不到一半。
