Battaglia C, Genazzani A D, Regnani G, Primavera M R, Petraglia F, Volpe A
Department of Obstetrics and Gynecology, University of Modena, Modena, Italy.
Fertil Steril. 2000 Oct;74(4):809-12. doi: 10.1016/s0015-0282(00)01517-x.
To prospectively evaluate follicular fluid levels of vascular endothelial growth factor in women undergoing IVF cycles and to investigate the correlation of these levels with ovarian response to gonadotropins and with uterine or ovarian Doppler findings.
Prospective study.
University hospital.
PATIENT(S): 41 patients undergoing ART were divided into two groups according to response to ovarian stimulation protocols: poor responders (n = 18) and normoresponders (n = 23).
INTERVENTION(S): Doppler analysis of perifollicular arteries and assay of follicular fluid vascular endothelial growth factor.
MAIN OUTCOME MEASURE(S): During ovarian stimulation, patients underwent hormonal (E2), ultrasonographic (follicular number and diameter, endometrial thickness) and Doppler (uterine and perifollicular arteries) evaluation. Serum and follicular fluid concentrations of vascular endothelial growth factor were assayed in each female patient.
RESULT(S): Compared with poor responders, more oocytes were collected and more embryos were transferred but follicular fluid levels of vascular endothelial growth factor levels were lower in normoresponders. Follicular fluid levels of vascular endothelial growth factor were inversely correlated with number of oocytes retrieved. Poor responders had significantly higher uterine and perifollicular Doppler flow resistances. The pregnancy rate per cycle was significantly higher in normoresponders (26%) than poor responders (6%).
CONCLUSION(S): Elevated follicular fluid levels of vascular endothelial growth factor concentrations are associated with poor ovarian response and a very low pregnancy rate.
前瞻性评估接受体外受精周期的女性卵泡液中血管内皮生长因子的水平，并研究这些水平与卵巢对促性腺激素的反应以及子宫或卵巢多普勒检查结果之间的相关性。
前瞻性研究。
大学医院。
41例接受辅助生殖技术治疗的患者根据对卵巢刺激方案的反应分为两组：反应不良者（n = 18）和反应正常者（n = 23）。
卵泡周围动脉的多普勒分析和卵泡液血管内皮生长因子的测定。
在卵巢刺激期间，患者接受激素（雌二醇）、超声检查（卵泡数量和直径、子宫内膜厚度）和多普勒检查（子宫和卵泡周围动脉）评估。测定每位女性患者血清和卵泡液中血管内皮生长因子的浓度。
与反应不良者相比，反应正常者收集的卵母细胞更多，移植的胚胎更多，但反应正常者卵泡液中血管内皮生长因子水平较低。卵泡液中血管内皮生长因子水平与回收的卵母细胞数量呈负相关。反应不良者子宫和卵泡周围的多普勒血流阻力明显更高。反应正常者每个周期的妊娠率（26%）明显高于反应不良者（6%）。
卵泡液中血管内皮生长因子浓度升高与卵巢反应不良和极低的妊娠率有关。
