Aplin J D
Academic Unit of Obstetrics and Gynaecology, School of Medicine and School of Biological Sciences, University of Manchester, UK.
Baillieres Best Pract Res Clin Obstet Gynaecol. 2000 Oct;14(5):757-64. doi: 10.1053/beog.2000.0116.
Understanding the cellular basis of implantation and placental development depends on a combination of the limited morphological evidence in the human with data from other primates, separate studies of pre-implantation embryos and endometrium and in vitro models. There is increasing evidence of a dialogue between embryo and endometrium that begins prior to implantation and evolves rapidly through the successive epithelial and stromal/vascular phases. This includes paracrine signals passing to endometrial tissue from the embryo, and vice versa. The production and timing of these signals by endometrium, and its ability to respond to signals from the blastocyst, are dependent on steroidal sensitization. A complex cascade of cell adhesion mechanisms and local tissue remodelling are required for the establishment of a stable haemochorial interface.
了解着床和胎盘发育的细胞基础，需要将人类有限的形态学证据与来自其他灵长类动物的数据、对植入前胚胎和子宫内膜的单独研究以及体外模型相结合。越来越多的证据表明，胚胎与子宫内膜之间的对话在着床前就已开始，并通过连续的上皮和基质/血管阶段迅速演变。这包括从胚胎传递到子宫内膜组织的旁分泌信号，反之亦然。子宫内膜产生这些信号的时间及其对囊胚信号的反应能力取决于甾体致敏作用。建立稳定的血绒毛膜界面需要复杂的细胞粘附机制和局部组织重塑过程。
