1933年至1980年伦敦东部石棉厂工人各类癌症的死亡率。
Mortality from all cancers of asbestos factory workers in east London 1933-80.
作者信息
Berry G, Newhouse M L, Wagner J C
机构信息
Department of Public Health and Community Medicine, University of Sydney, New South Wales 2006, Australia.
出版信息
Occup Environ Med. 2000 Nov;57(11):782-5. doi: 10.1136/oem.57.11.782.
OBJECTIVE
To give the observed and expected deaths due to cancer at all separate sites in asbestos workers in east London, and to analyse these for overall effect and exposure-response trend.
METHODS
The mortality experience of a cohort of over 5000 men and women followed up for over 30 years since first exposure to asbestos has been extracted.
RESULTS
There was a large excess of deaths due to cancer (537 observed, 222 expected). Most of these were due to cancer of the lung (232 observed, 77 expected) and pleural (52) and peritoneal (48) mesothelioma. The exposure-response trend for all these three causes was highly significant. There was also an excess of cancer of the colon (27 observed, 15 expected) which was significantly related to exposure. There were significant excesses of cancer of the ovary, of the liver, and of the oesophagus but with no consistent relation to exposure.
CONCLUSIONS
The excess risk of cancer after exposure to asbestos was mainly due to cancer of the lung and mesothelioma. An exposure related excess of cancer of the colon was also detected but the possibility that some of these deaths may have been peritoneal mesotheliomas could not be excluded. There was no consistent evidence of exposure related excesses at any other site.
目的
给出东伦敦石棉工人各个部位因癌症导致的观察到的死亡人数和预期死亡人数，并分析总体影响和暴露-反应趋势。
方法
提取了一组5000多名男性和女性自首次接触石棉以来长达30多年的随访死亡率数据。
结果
癌症导致的死亡人数大幅超标（观察到537例，预期222例）。其中大部分是肺癌（观察到232例，预期77例）以及胸膜（52例）和腹膜（48例）间皮瘤。这三种病因的暴露-反应趋势都非常显著。结肠癌也有超标（观察到27例，预期15例），且与暴露显著相关。卵巢癌、肝癌和食管癌也有显著超标，但与暴露没有一致的关联。
结论
接触石棉后癌症风险超标主要归因于肺癌和间皮瘤。还检测到与暴露相关的结肠癌超标，但不能排除其中一些死亡可能是腹膜间皮瘤的可能性。没有一致的证据表明在任何其他部位存在与暴露相关的超标情况。
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