Tolou H, Couissinier-Paris P, Mercier V, Pisano M R, de Lamballerie X, de Micco P, Durand J P
Unité de Virologie Tropicale, Institut de Médecine Tropicale du Service de Santé des Armées.
Biochem Biophys Res Commun. 2000 Oct 14;277(1):89-92. doi: 10.1006/bbrc.2000.3640.
Severe forms of dengue fever, dengue haemorrhagic fever, and dengue shock syndrome, were not prominent in the Americas until the epidemic of Cuba in 1981. Since that time, they have spread to other countries in Central and South America, correlating with the spread of dengue type 2 viruses related to Southeast Asian strains. We report here the complete genomic sequence of a dengue type 2 virus isolated during the epidemic in La Martinique in 1998. This constitutes the first complete genetic characterization of a dengue virus strain from French West Indies, and also the first molecular identification in this region of a dengue 2 strain phylogenetically related to the emerging American type 2 dengue viruses.
严重型登革热、登革出血热和登革休克综合征，直到1981年古巴流行时才在美洲凸显出来。自那时起，它们已传播到中美洲和南美洲的其他国家，这与源自东南亚毒株的2型登革病毒的传播相关。我们在此报告1998年在马提尼克岛流行期间分离出的一株2型登革病毒的完整基因组序列。这是来自法属西印度群岛的登革病毒株的首次完整基因特征分析，也是该地区对与新兴的美洲2型登革病毒在系统发育上相关的2型登革病毒株的首次分子鉴定。
