Villabona-Arenas Christian Julián, Miranda-Esquivel Daniel Rafael, Jimenez Raquel Elvira Ocazionez
Laboratorio de Sistemática & Biogeografía, Escuela de Biología, Universidad Industrial de Santander, Bucaramanga A.A. 678, Colombia.
Trop Med Int Health. 2009 Oct;14(10):1241-50. doi: 10.1111/j.1365-3156.2009.02339.x. Epub 2009 Jul 8.
Dengue virus type 3 (DENV-3) re-appeared in Colombia in 2001 after 23 years of apparent absence, in the state of Santander in the North-eastern region near to Venezuelan border. In 2002, the virus was isolated in the state of Valle del Cauca in the South-east region near to Ecuadorian/Peruvian border, and in the state of Antioquia in the North-east region near to Panama border. To gain insight into the molecular epidemiology of DENV-3 in Colombia, we sequenced the complete E gene of 21 isolates sampled in the period 2001-2007. Phylogenetic analyses revealed that Colombian strains seem to have been introduced from Venezuela, Ecuador and Peru, but not from Brazil, Argentina, Paraguay or Central America countries. This study also confirms previous report showing that Colombian isolates is closely related to DENV-3 genotype III.
登革热3型病毒（DENV-3）在明显消失23年后，于2001年在靠近委内瑞拉边境的东北部桑坦德省重新出现在哥伦比亚。2002年，该病毒在靠近厄瓜多尔/秘鲁边境的东南部考卡山谷省以及靠近巴拿马边境的东北部安蒂奥基亚省被分离出来。为深入了解哥伦比亚DENV-3的分子流行病学，我们对2001年至2007年期间采集的21株病毒的完整E基因进行了测序。系统发育分析表明，哥伦比亚毒株似乎是从委内瑞拉、厄瓜多尔和秘鲁引入的，而非来自巴西、阿根廷、巴拉圭或中美洲国家。这项研究还证实了之前的报告，即哥伦比亚分离株与DENV-3基因型III密切相关。
