Ugi I K, Ebert B, Hörl W
Lehrstuhl I für Organische Chemie und Biochemie der Technischen Universität, Garching, Germany.
Chemosphere. 2001 Apr;43(1):75-81. doi: 10.1016/s0045-6535(00)00326-x.
The combination of multicomponent reactions (MCRs) of different amino acids, aldehydes, isocyanides and acids allows complex structures to be prepared in one-pot reactions. The synthesis of 1,1'-iminodicarboxylic acid derivatives 12 demonstrates the high selectivity of the Ugi Four Component Reaction using two different aldehydes and two different isocyanides. The limitations of the MCRs are illustrated by the synthesis of a 1,1'-iminodicarboxylic acid derivative 6 from L-lysine. Furthermore, 2,6-diketopiperazines and dibenzodiazocin-2,6-diones are synthesized via MCRs.
不同氨基酸、醛、异腈和酸的多组分反应（MCRs）相结合，使得复杂结构能够通过一锅法反应制备。1,1'-亚氨基二羧酸衍生物12的合成证明了使用两种不同醛和两种不同异腈的乌吉四组分反应具有高选择性。从L-赖氨酸合成1,1'-亚氨基二羧酸衍生物6说明了MCRs的局限性。此外，通过MCRs合成了2,6-二酮哌嗪和二苯并二氮杂䓬-2,6-二酮。
