Mårtensson L, Nyberg K, Wallin G
Department of Health Sciences, University of Skövde, Sweden.
BJOG. 2000 Oct;107(10):1248-51. doi: 10.1111/j.1471-0528.2000.tb11615.x.
To investigate whether, during injections of sterile water, there is any difference in perceived pain between intracutaneous and subcutaneous injections.
Blind controlled trial with cross-over design.
Göteborg and Skövde, Sweden.
One hundred healthy female volunteers.
The women were randomised into two groups and subjected to two trials, within one week of each other. During the first trial one group (n = 50) received the intracutaneous injection first, followed by the subcutaneous injection. The second group (n = 50) was given the subcutaneous injection first, followed by intracutaneous injection. In both groups all the injections were given in reverse order during the second trial.
Experienced pain during the administration of sterile water injections, measured by visual analogue scale.
The analysis showed intracutaneous injections to be significantly more painful than subcutaneous injections, even after adjusting for injection day and for left/right site of injection (mean 60.8 vs 41.3, P < 0.001).
The findings suggest that the less painful subcutaneous injection technique should be used.
研究在注射无菌水时，皮内注射和皮下注射在感知疼痛方面是否存在差异。
采用交叉设计的盲法对照试验。
瑞典哥德堡和舍夫德。
100名健康女性志愿者。
将这些女性随机分为两组，并在一周内进行两次试验。在第一次试验中，一组（n = 50）先接受皮内注射，然后接受皮下注射。第二组（n = 50）先接受皮下注射，然后接受皮内注射。在第二次试验中，两组的所有注射顺序均相反。
通过视觉模拟量表测量注射无菌水时的疼痛感受。
分析表明，即使在调整注射日期和注射部位的左右侧后，皮内注射仍比皮下注射疼痛得多（平均60.8对41.3，P < 0.001）。
研究结果表明应采用疼痛较轻的皮下注射技术。
