Patrizi A, D'Acunto C, Passarini B, Neri I
Department of Clinical and Experimental Medicine, University of Bologna, Italy.
Acta Derm Venereol. 2000 Jul-Aug;80(4):302-4. doi: 10.1080/000155500750012243.
In a review of all cases of porokeratosis histologically diagnosed in our Department during the period 1991-98 we found that 12 patients (22%) were in their seventh to ninth decade. In all 12 (2 males and 10 females) the age of onset of the disease varied between 58 and 89 years (mean age 68.6 years). The clinical picture was similar in all the patients, with the number of lesions varying from a few to 20-50 annular plaques 10-15 mm in diameter, localized mainly on the lower limbs. We suggest that our patients had a very mild form of disseminated superficial actinic porokeratosis confined to the extremities with an unusually late onset. This peculiar variety of late-onset disseminated superficial actinic porokeratosis may represent a type of immunosuppression-induced porokeratosis where the pathologic clone for porokeratosis is present but remains latent until the amount of sun exposure, together with the physiological age-related lowering of immunocompetence, bring about its proliferation.
在回顾1991年至1998年期间在我们科室经组织学诊断的所有汗孔角化症病例时，我们发现12名患者（占22%）年龄在70到90岁之间。这12名患者（2名男性和10名女性）中，疾病的发病年龄在58岁至89岁之间（平均年龄68.6岁）。所有患者的临床表现相似，皮损数量从几个到20至50个直径为10至15毫米的环状斑块不等，主要分布在下肢。我们认为，我们的患者患有一种非常轻微的局限于四肢的播散性浅表性光化性汗孔角化症，发病异常晚。这种特殊类型的迟发性播散性浅表性光化性汗孔角化症可能代表一种免疫抑制诱导的汗孔角化症，其中存在汗孔角化症的病理克隆，但直到日晒量与与年龄相关的生理免疫能力下降共同导致其增殖之前，该克隆一直处于潜伏状态。
