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Fruit and vegetable intake in relation to risk of ischemic stroke.水果和蔬菜摄入量与缺血性中风风险的关系。
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Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study.空腹总同型半胱氨酸、相关基因多态性及B族维生素与冠心病发病率的前瞻性研究：社区动脉粥样硬化风险（ARIC）研究
Circulation. 1998 Jul 21;98(3):204-10. doi: 10.1161/01.cir.98.3.204.
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Homocysteine and atherothrombosis.同型半胱氨酸与动脉粥样硬化血栓形成
N Engl J Med. 1998 Apr 9;338(15):1042-50. doi: 10.1056/NEJM199804093381507.
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Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.饮食及补充剂中的叶酸和维生素B6与女性冠心病风险的关系
JAMA. 1998 Feb 4;279(5):359-64. doi: 10.1001/jama.279.5.359.
5
Homocysteine metabolism and risk of myocardial infarction: relation with vitamins B6, B12, and folate.同型半胱氨酸代谢与心肌梗死风险：与维生素B6、B12和叶酸的关系。
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The logic in ecological: I. The logic of analysis.生态学中的逻辑：一、分析的逻辑。
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Invited commentary: ecologic studies--biases, misconceptions, and counterexamples.特邀评论：生态学研究——偏差、误解及反例
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[Mortality from ischemic cardiopathy in Spain: the trends and geographic distribution].[西班牙缺血性心脏病死亡率：趋势与地理分布]
Rev Esp Cardiol. 1995 Feb;48(2):106-14.
10
Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis.血浆同型半胱氨酸浓度与颅外颈动脉狭窄之间的关联。
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西班牙饮食中叶酸、维生素B6和维生素B12与心血管疾病死亡率的关联：一项生态学分析

The association of dietary folate, B6, and B12 with cardiovascular mortality in Spain: an ecological analysis.

作者信息

Medrano M J, Sierra M J, Almazán J, Olalla M T, López-Abente G

机构信息

National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain.

出版信息

Am J Public Health. 2000 Oct;90(10):1636-8. doi: 10.2105/ajph.90.10.1636.

DOI:10.2105/ajph.90.10.1636
PMID:11030004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1446360/
Abstract

OBJECTIVES

This study assessed the association of dietary folate, vitamin B6, and vitamin B12 with cardiovascular mortality.

METHODS

Poisson regression analyses assessed coronary/cerebrovascular mortality rates via nutrient data obtained from the National Nutrition Survey, which recorded 7-day food intakes from a national sample of 21,155 households.

RESULTS

In regard to coronary mortality, male and female rate ratios (highest vs lowest quintile) were 0.83 (95% confidence interval [CI] = 0.77, 0.91) and 0.95 (95% CI = 0.86, 1.05), respectively, for folate and 0.74 (95% CI = 0.65, 0.84) and 0.86 (95% CI = 0.73, 0.99), respectively, for B12. Intake of folate and B6 (but not B12) was significantly associated with cerebrovascular mortality.

CONCLUSIONS

B vitamins are associated with cardiovascular mortality in the general population.

摘要

目的

本研究评估膳食叶酸、维生素B6和维生素B12与心血管疾病死亡率之间的关联。

方法

通过泊松回归分析，利用从国家营养调查中获取的营养数据评估冠状动脉/脑血管疾病死亡率，该调查记录了来自21155户家庭全国样本的7天食物摄入量。

结果

就冠状动脉死亡率而言，叶酸的男性和女性率比（最高五分位数与最低五分位数相比）分别为0.83（95%置信区间[CI]=0.77,0.91）和0.95（95%CI=0.86,1.05），维生素B12的分别为0.74（95%CI=0.65,0.84）和0.86（95%CI=0.73,0.99）。叶酸和维生素B6（而非维生素B12）的摄入量与脑血管死亡率显著相关。

结论

B族维生素与普通人群的心血管疾病死亡率相关。