西班牙饮食中叶酸、维生素B6和维生素B12与心血管疾病死亡率的关联：一项生态学分析
The association of dietary folate, B6, and B12 with cardiovascular mortality in Spain: an ecological analysis.
作者信息
Medrano M J, Sierra M J, Almazán J, Olalla M T, López-Abente G
机构信息
National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain.
出版信息
Am J Public Health. 2000 Oct;90(10):1636-8. doi: 10.2105/ajph.90.10.1636.
Abstract
OBJECTIVES
This study assessed the association of dietary folate, vitamin B6, and vitamin B12 with cardiovascular mortality.
METHODS
Poisson regression analyses assessed coronary/cerebrovascular mortality rates via nutrient data obtained from the National Nutrition Survey, which recorded 7-day food intakes from a national sample of 21,155 households.
RESULTS
In regard to coronary mortality, male and female rate ratios (highest vs lowest quintile) were 0.83 (95% confidence interval [CI] = 0.77, 0.91) and 0.95 (95% CI = 0.86, 1.05), respectively, for folate and 0.74 (95% CI = 0.65, 0.84) and 0.86 (95% CI = 0.73, 0.99), respectively, for B12. Intake of folate and B6 (but not B12) was significantly associated with cerebrovascular mortality.
CONCLUSIONS
B vitamins are associated with cardiovascular mortality in the general population.
摘要
目的
本研究评估膳食叶酸、维生素B6和维生素B12与心血管疾病死亡率之间的关联。
方法
通过泊松回归分析，利用从国家营养调查中获取的营养数据评估冠状动脉/脑血管疾病死亡率，该调查记录了来自21155户家庭全国样本的7天食物摄入量。
结果
就冠状动脉死亡率而言，叶酸的男性和女性率比（最高五分位数与最低五分位数相比）分别为0.83（95%置信区间[CI]=0.77,0.91）和0.95（95%CI=0.86,1.05），维生素B12的分别为0.74（95%CI=0.65,0.84）和0.86（95%CI=0.73,0.99）。叶酸和维生素B6（而非维生素B12）的摄入量与脑血管死亡率显著相关。
结论
B族维生素与普通人群的心血管疾病死亡率相关。
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