de Pedro-Cuesta Jesús, Virués-Ortega Javier, Vega Saturio, Seijo-Martínez Manuel, Saz Pedro, Rodríguez Fernanda, Rodríguez-Laso Angel, Reñé Ramón, de las Heras Susana Pérez, Mateos Raimundo, Martínez-Martín Pablo, Manubens José María, Mahillo-Fernandez Ignacio, López-Pousa Secundino, Lobo Antonio, Reglà Jordi Llinàs, Gascón Jordi, García Francisco José, Fernández-Martínez Manuel, Boix Raquel, Bermejo-Pareja Félix, Bergareche Alberto, Benito-León Julián, de Arce Ana, del Barrio José Luis
National Centre for Epidemiology, CIBERNED and Alzheimer' Disease Research Unit, Carlos III Institute of Public Health, Madrid, Spain.
BMC Neurol. 2009 Oct 19;9:55. doi: 10.1186/1471-2377-9-55.
This study describes the prevalence of dementia and major dementia subtypes in Spanish elderly.
We identified screening surveys, both published and unpublished, in Spanish populations, which fulfilled specific quality criteria and targeted prevalence of dementia in populations aged 70 years and above. Surveys covering 13 geographically different populations were selected (prevalence period: 1990-2008). Authors of original surveys provided methodological details of their studies through a systematic questionnaire and also raw age-specific data. Prevalence data were compared using direct adjustment and logistic regression.
The reanalyzed study population (aged 70 year and above) was composed of Central and North-Eastern Spanish sub-populations obtained from 9 surveys and totaled 12,232 persons and 1,194 cases of dementia (707 of Alzheimer's disease, 238 of vascular dementia). Results showed high variation in age- and sex-specific prevalence across studies. The reanalyzed prevalence of dementia was significantly higher in women; increased with age, particularly for Alzheimer's disease; and displayed a significant geographical variation among men. Prevalence was lowest in surveys reporting participation below 85%, studies referred to urban-mixed populations and populations diagnosed by psychiatrists.
Prevalence of dementia and Alzheimer's disease in Central and North-Eastern Spain is higher in females, increases with age, and displays considerable geographic variation that may be method-related. People suffering from dementia and Alzheimer's disease in Spain may approach 600,000 and 400,000 respectively. However, existing studies may not be completely appropriate to infer prevalence of dementia and its subtypes in Spain until surveys in Southern Spain are conducted.
本研究描述了西班牙老年人中痴呆症及主要痴呆症亚型的患病率。
我们在西班牙人群中识别出已发表和未发表的筛查调查，这些调查符合特定质量标准，目标是70岁及以上人群中的痴呆症患病率。选择了涵盖13个地理上不同人群的调查（患病率时期：1990 - 2008年）。原始调查的作者通过系统问卷提供了他们研究的方法细节以及按年龄分类的原始数据。使用直接调整和逻辑回归比较患病率数据。
重新分析的研究人群（70岁及以上）由从9项调查中获得的西班牙中部和东北部亚人群组成，共计12,232人，1,194例痴呆症患者（707例阿尔茨海默病，238例血管性痴呆）。结果显示，各研究中按年龄和性别分类的患病率差异很大。重新分析的痴呆症患病率在女性中显著更高；随年龄增加，尤其是阿尔茨海默病；并且在男性中显示出显著的地理差异。在报告参与率低于85%的调查、涉及城市混合人群的研究以及由精神科医生诊断的人群中，患病率最低。
西班牙中部和东北部痴呆症及阿尔茨海默病的患病率在女性中更高，随年龄增加，并且显示出相当大的地理差异，这可能与方法有关。西班牙患有痴呆症和阿尔茨海默病的人数可能分别接近60万和40万。然而，在西班牙南部进行调查之前，现有研究可能不完全适合推断西班牙痴呆症及其亚型的患病率。
