分裂型人格障碍中的偏侧化P3波缺失
Lateralized P3 deficit in schizotypal personality disorder.
作者信息
Niznikiewicz M A, Voglmaier M M, Shenton M E, Dickey C C, Seidman L J, Teh E, Van Rhoads R, McCarley R W
机构信息
Harvard Medical School Department of Psychiatry, Brockton/West Roxbury VAMC, Brockton, Massachusetts 02301, USA.
出版信息
Biol Psychiatry. 2000 Oct 1;48(7):702-5. doi: 10.1016/s0006-3223(00)00938-0.
Abstract
BACKGROUND
Reduced, left-lateralized P3 amplitude has been reported in several studies focusing on electrophysiologic function in schizophrenia. Also, several lines of evidence suggest a similarity between schizophrenia and schizotypal personality disorder (SPD). This study was undertaken to determine the replicability of our previous finding of a left-lateralized P3 amplitude deficit in SPD.
METHODS
We recorded event-related potentials in 21 SPD and 18 normal control subjects in an auditory "oddball" P3 paradigm.
RESULTS
In the SPD subjects, but not in the control subjects, there was lower P3 amplitude at T3 compared with T4.
CONCLUSIONS
These results are similar to the ones in our previous work and further support the presence of a left-lateralized P3 deficit in SPD.
摘要
背景
在多项聚焦于精神分裂症电生理功能的研究中，均报告了P3波幅降低且呈左侧化。此外，有多项证据表明精神分裂症与分裂型人格障碍（SPD）存在相似性。本研究旨在确定我们之前在SPD中发现的左侧化P3波幅缺陷的可重复性。
方法
我们在21名SPD患者和18名正常对照受试者中，采用听觉“oddball”P3范式记录事件相关电位。
结果
在SPD受试者中，与T4相比，T3处的P3波幅较低，而在对照受试者中则未出现这种情况。
结论
这些结果与我们之前的研究结果相似，进一步支持了SPD中存在左侧化P3缺陷。
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