McKinney E T, Shouri R, Hunt R S, Ahokas R A, Sibai B M
Department of Obstetrics and Gynecology, The University of Tennessee, Memphis, TN, USA.
Am J Obstet Gynecol. 2000 Oct;183(4):874-7. doi: 10.1067/mob.2000.108877.
Our purpose was to measure and compare plasma, urinary, and salivary concentrations of 8-epi-prostaglandin F(2alpha) (8-isoprostane) in women with normotensive pregnancies and the respective concentrations in pregnancies complicated by preeclampsia.
Plasma, urinary, and salivary 8-isoprostane levels were measured in pregnant women with preeclampsia (n = 40), normotensive pregnant women (n = 20), and nonpregnant women (n = 10). One-way analysis of variance was used to determine significant differences.
Plasma free 8-isoprostane concentrations were increased in women with severe preeclampsia (342 +/- 50 pg/mL), in comparison with nonpregnant women (129 +/- 17 pg/mL) and normotensive pregnant women (150 +/- 11 pg/mL; P =.003, and.0001, respectively). Urinary excretion of 8-isoprostane was slightly but not significantly decreased in preeclampsia (1200 +/- 227 pg/mL), in comparison with urinary excretion in nonpregnant women (1625 +/- 364 pg/mL) and normotensive pregnant women (2149 +/- 432 pg/mL). Salivary concentrations of 8-isoprostane were increased in normotensive women (496 +/- 113 pg/mL), in comparison with nonpregnant women (150 +/- 27 pg/mL) but were not related to preeclampsia (419 +/- 96 pg/mL; P </=.003).
Free 8-isoprostane concentrations are increased in the plasma of women with severe preeclampsia. Further studies are warranted to determine whether such increases are caused by an increase in phospholipase A(2) activity, or by lipid peroxidation, or by a decrease in renal excretion.
我们的目的是测量并比较血压正常孕妇与并发先兆子痫孕妇的血浆、尿液及唾液中8-表-前列腺素F（2α）（8-异前列腺素）的浓度。
对患有先兆子痫的孕妇（n = 40）、血压正常的孕妇（n = 20）及未怀孕女性（n = 10）测量其血浆、尿液及唾液中8-异前列腺素水平。采用单因素方差分析来确定显著差异。
与未怀孕女性（129±17 pg/mL）及血压正常的孕妇（150±11 pg/mL）相比，重度先兆子痫女性的血浆游离8-异前列腺素浓度升高（342±50 pg/mL）；P值分别为0.003及0.0001。与未怀孕女性（1625±364 pg/mL）及血压正常的孕妇（2149±432 pg/mL）的尿排泄量相比，先兆子痫患者的8-异前列腺素尿排泄量略有下降，但无显著差异（1200±227 pg/mL）。与未怀孕女性（150±27 pg/mL）相比，血压正常女性的唾液8-异前列腺素浓度升高（496±113 pg/mL），但与先兆子痫无关（419±96 pg/mL；P≤0.003）。
重度先兆子痫女性血浆中的游离8-异前列腺素浓度升高。有必要进一步研究以确定这种升高是由磷脂酶A（2）活性增加、脂质过氧化增加还是肾排泄减少所致。
