Ring C, Harrison L K, Winzer A, Carroll D, Drayson M, Kendall M
School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, UK.
Psychophysiology. 2000 Sep;37(5):634-43.
The mechanism underlying acute changes in secretory immunoglobulin A (sIgA) remains to be determined. In this experiment, sIgA and cardiovascular activity were monitored at rest and while participants performed a mental arithmetic task, cold pressor, and submaximal cycle exercise following placebo or 1 mg of the alpha-adrenergic blocker, doxazosin. Under placebo, the tasks produced patterns of cardiovascular activity indicative of combined alpha- and beta-adrenergic, alpha-adrenergic, and beta-adrenergic activation, respectively. Doxazosin was associated with reduced blood pressure during cold pressor, but not during arithmetic or exercise. Mental arithmetic elicited increases in sIgA concentration and exercise produced increases in both sIgA concentration and secretion rate; these changes were unaffected by alpha blockade. In contrast, the cold pressor was associated with decreases in both sIgA concentration and secretion rate, which were blocked by doxazosin. These data suggest that acute decreases, but not increases, in sIgA are mediated by alpha-adrenergic mechanisms.
分泌型免疫球蛋白A（sIgA）急性变化的潜在机制仍有待确定。在本实验中，在参与者休息时以及在服用安慰剂或1毫克α-肾上腺素能阻滞剂多沙唑嗪后进行心算任务、冷加压试验和次最大强度自行车运动时，监测sIgA和心血管活动。在安慰剂作用下，这些任务分别产生了表明α-和β-肾上腺素能联合激活、α-肾上腺素能激活和β-肾上腺素能激活的心血管活动模式。多沙唑嗪与冷加压试验期间血压降低有关，但在心算或运动期间无关。心算引起sIgA浓度升高，运动引起sIgA浓度和分泌率均升高；这些变化不受α-受体阻滞的影响。相反，冷加压试验与sIgA浓度和分泌率降低有关，而多沙唑嗪可阻断这些降低。这些数据表明，sIgA的急性降低而非升高是由α-肾上腺素能机制介导的。
