Gomot M, Giard M H, Roux S, Barthélémy C, Bruneau N
INSERM U316, Child Psychiatry Unit, CHU Bretonneau, Tours, France.
Neuroreport. 2000 Sep 28;11(14):3109-12. doi: 10.1097/00001756-200009280-00014.
The mismatch negativity (MMN) response of auditory ERPs in adults appears to result from several overlapping components involving both frontal and temporal brain areas. Our aim was to test whether a similar configuration could be observed in children, and to examine the maturation rates of the different components. MMN (standard tones: 1000 Hz, deviants: 1100 Hz) was recorded from 28 scalp electrodes in 24 healthy children aged from 5 to 10 and in eight adults for comparison. Scalp current density analysis revealed both temporal and frontal components in children of all ages as well as in adults. Moreover the amplitudes of the temporal components were significantly greater in children than in adults, whereas the frontal components were similar at all ages. The results strongly suggest that MMN is mediated by at least two separate neural systems, and that the frontal system matures earlier than the sensory-specific system.
成人听觉事件相关电位的失匹配负波（MMN）反应似乎源于涉及额叶和颞叶脑区的几个重叠成分。我们的目的是测试在儿童中是否能观察到类似的结构，并检查不同成分的成熟速率。对24名年龄在5至10岁的健康儿童和8名成年人进行记录，从28个头皮电极记录MMN（标准音调：1000赫兹，偏差音调：1100赫兹）以供比较。头皮电流密度分析显示，所有年龄段的儿童以及成年人都有颞叶和额叶成分。此外，儿童颞叶成分的振幅显著大于成年人，而额叶成分在所有年龄段都相似。结果强烈表明，MMN由至少两个独立的神经系统介导，并且额叶系统比感觉特异性系统成熟得更早。
