Solomonia R O, Kiguradze T, McCabe B J, Horn G
Institute of Physiology, Georgian Academy of Sciences, Tbilisi, Republic of Georgia.
Neuroreport. 2000 Sep 28;11(14):3139-43. doi: 10.1097/00001756-200009280-00020.
The intermediate and medial hyperstriatum ventrale (IMHV) of the chick brain is a site of recognition memory for filial imprinting. Previous results have demonstrated learning-related changes in the amounts of the three major isoforms of neural cell adhesion molecule (NCAM) in the left IMHV. The increases were present 24 h after training. The present study enquired whether the increases persisted and were present 48 h after training. The brain regions analysed were the left and right IMHV and the left and right hyperstriatum accessorium (HA), a visual projection area. The alpha-subunit of calcium/calmodulin protein kinase II (CaMKIIalpha) was also assayed. There were significant correlations between a measure of the strength of learning and the amount of NCAM 180 in the right IMHV (r = +0.65; p = 0.012) but not in the left, and in the left HA (r = -0.61; p = 0.02), but not in the right. There were no learning-related changes for CaMKIIalpha. We conclude that in IMHV the effects of imprinting on NCAM 180 are expressed mainly in the left IMHV 24 h after training, but 48 h after training are expressed mainly in the right IMHV.
雏鸡脑的中间和内侧腹侧上纹状体（IMHV）是亲子印记识别记忆的一个位点。先前的研究结果表明，左侧IMHV中神经细胞黏附分子（NCAM）三种主要同工型的含量存在与学习相关的变化。这些增加在训练后24小时出现。本研究探讨这些增加是否持续存在以及在训练后48小时是否出现。所分析的脑区为左右IMHV以及左右副上纹状体（HA），一个视觉投射区域。还检测了钙/钙调蛋白蛋白激酶II（CaMKIIα）的α亚基。学习强度指标与右侧IMHV中NCAM 180的含量之间存在显著相关性（r = +0.65；p = 0.012），但左侧不存在，并且与左侧HA中NCAM 180的含量存在显著相关性（r = -0.61；p = 0.02），但右侧不存在。CaMKIIα没有与学习相关的变化。我们得出结论，在IMHV中，印记对NCAM 180的影响在训练后24小时主要表现在左侧IMHV，但在训练后48小时主要表现在右侧IMHV。
