Van den Hurk R, Abir R, Telfer E E, Bevers M M
Department of Farm Animal Health, Veterinary Faculty, Utrecht University, The Netherlands.
Hum Reprod Update. 2000 Sep-Oct;6(5):457-74. doi: 10.1093/humupd/6.5.457.
This review discusses the mechanisms underlying ovarian follicle development and the potential of immature follicles and oocytes from non-rodent mammalian species particularly human and bovine to serve as sources of oocytes for the in-vitro production of embryos. Factors that regulate growth and differentiation of unilaminar (primordial and primary) and multilaminar (secondary) follicles and the maturation of oocytes are highlighted. We conclude that many obstacles must still be overcome before fertilizable oocytes can be obtained from human and bovine ovaries, and more research on the quality of and culture conditions for immature oocytes and follicles is required before these can be considered as a source for in-vitro production.
本综述讨论了卵巢卵泡发育的潜在机制，以及来自非啮齿类哺乳动物（尤其是人类和牛）的未成熟卵泡和卵母细胞作为体外胚胎生产的卵母细胞来源的可能性。文中强调了调节单层（原始卵泡和初级卵泡）和多层（次级卵泡）卵泡生长与分化以及卵母细胞成熟的因素。我们得出结论，在从人类和牛的卵巢中获得可受精的卵母细胞之前，仍有许多障碍需要克服，并且在将未成熟卵母细胞和卵泡视为体外生产的来源之前，还需要对其质量和培养条件进行更多研究。
