Dunn C J, Willoughby D A
J Pathol. 1975 Aug;116(4):195-201. doi: 10.1002/path.1711160402.
Histopathological investigations of skin lesions induced by subcutaneous implantation of glass coverslips were carried out in rats between birth and adulthood. Differences were found between the cellular reactions of newborn and adult rats to this irritant. An increased number of cells was found in the skin lesions of newborn rats, compared with adults. Uptake of a 30-min. pulse of tritiated thymidine by mononuclear cells was found to be higher in newborn skin lesions than in those of adult rats. The reverse was observed for the mononuclear cells adherent to implanted glass coverslips. Giant cells were less evident on coverslips removed from the skin of newborn rats.
对出生至成年大鼠皮下植入玻璃盖玻片所致皮肤损伤进行了组织病理学研究。发现新生大鼠和成年大鼠对这种刺激物的细胞反应存在差异。与成年大鼠相比，新生大鼠皮肤损伤中的细胞数量增加。发现新生大鼠皮肤损伤中单核细胞对氚标记胸腺嘧啶核苷30分钟脉冲的摄取高于成年大鼠。而对于粘附在植入玻璃盖玻片上的单核细胞则观察到相反的情况。从新生大鼠皮肤中取出的盖玻片上巨细胞不太明显。
