Das K, Jain A, Gupta S, Kapoor S, Gupta R K, Chakravorty A, Kar P
Department of Medicine, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, India.
Eur J Epidemiol. 2000 Jun;16(6):507-10. doi: 10.1023/a:1007628021661.
The present study was undertaken to determine the seroprevalence of the antibody against hepatitis A virus (IgG anti-HAV) in an urban population sample from Delhi (India) and to assess any change in the epidemiological pattern of HAV infection in this part of the world. A total of 500 healthy subjects were enrolled and divided into groups on the basis of age, sex and per capita income and evaluated for the presence of IgG anti HAV antibodies using a commercially available kit. The mean age of all the subjects was 32.6 +/- 13.2 yr. and the male:female ratio was 1.5:1. The overall prevalence of IgG anti-HAV in all subjects was 71.2% (356/500). The prevalence in subjects >35 years (92.1% [186/202]) was significantly higher than that in subjects <35 years (92.1% [186/202]) was significantly higher than in subjects <35 years (57% [170/298]). No statistically significant difference was observed between male and female subjects (71.4% [217/304] vs. 70.9% [139/196]) or between subjects belonging to middle and low socioeconomic groups (68.9% [135/196] vs. 72.7% [221/304]). These findings when compared with the results that were obtained in 1982, showed a decreasing prevalence of IgG anti-HAV, most significantly in younger age groups (16-35 years). Thus, we may conclude that the seroepidemiology of hepatitis A virus infection in urban population of India seems to be changing with seroprevalence in the younger population approaching a figure similar to that of the more developed European countries.
本研究旨在确定印度德里城市人口样本中甲型肝炎病毒抗体（IgG抗-HAV）的血清流行率，并评估世界该地区甲型肝炎病毒感染流行病学模式的任何变化。共招募了500名健康受试者，并根据年龄、性别和人均收入进行分组，使用市售试剂盒评估IgG抗-HAV抗体的存在情况。所有受试者的平均年龄为32.6±13.2岁，男女比例为1.5:1。所有受试者中IgG抗-HAV的总体流行率为71.2%（356/500）。35岁以上受试者的流行率（92.1%[186/202]）显著高于35岁以下受试者（57%[170/298]）。男性和女性受试者之间（71.4%[217/304]对70.9%[139/196]）或社会经济地位中等和低等的受试者之间（68.9%[135/196]对72.7%[221/304]）未观察到统计学显著差异。与1982年获得的结果相比，这些发现表明IgG抗-HAV的流行率在下降，在较年轻年龄组（16 - 35岁）中最为显著。因此，我们可以得出结论，印度城市人口中甲型肝炎病毒感染的血清流行病学似乎正在发生变化，年轻人群中的血清流行率接近更发达的欧洲国家。
