Bodosi B, Obál F, Gardi J, Komlódi J, Fang J, Krueger J M
Department of Physiology, Albert Szent-Györgyi Medical University, 6720 Szeged, Hungary.
Am J Physiol Regul Integr Comp Physiol. 2000 Nov;279(5):R1590-8. doi: 10.1152/ajpregu.2000.279.5.R1590.
Sleep alterations after a 1-min exposure to ether vapor were studied in rats to determine if this stressor increases rapid eye-movement (REM) sleep as does an immobilization stressor. Ether exposure before light onset or dark onset was followed by significant increases in REM sleep starting approximately 3-4 h later and lasting for several hours. Non-REM (NREM) sleep and electroencephalographic slow-wave activity during NREM sleep were not altered. Exposure to ether vapor elicited prolactin (Prl) secretion. REM sleep was not promoted after ether exposure in hypophysectomized rats. If the hypophysectomy was partial and the rats secreted Prl after ether exposure, then increases in REM sleep were observed. Intracerebroventricular administration of an antiserum to Prl decreased spontaneous REM sleep and inhibited ether exposure-induced REM sleep. The results indicate that a brief exposure to ether vapor is followed by increases in REM sleep if the Prl response associated with stress is unimpaired. This suggests that Prl, which is a previously documented REM sleep-promoting hormone, may contribute to the stimulation of REM sleep after ether exposure.
为确定这种应激源是否像固定应激源那样增加快速眼动（REM）睡眠，研究了大鼠暴露于乙醚蒸汽1分钟后的睡眠改变情况。在光照开始前或黑暗开始前暴露于乙醚后，大约3 - 4小时后REM睡眠显著增加，并持续数小时。非快速眼动（NREM）睡眠以及NREM睡眠期间的脑电图慢波活动未发生改变。暴露于乙醚蒸汽会引起催乳素（Prl）分泌。垂体切除的大鼠在暴露于乙醚后REM睡眠未增加。如果垂体切除是部分切除且大鼠在暴露于乙醚后分泌Prl，那么就会观察到REM睡眠增加。脑室内注射抗Prl抗血清会减少自发性REM睡眠并抑制乙醚暴露诱导的REM睡眠。结果表明，如果与应激相关的Prl反应未受损，那么短暂暴露于乙醚蒸汽后REM睡眠会增加。这表明Prl是一种先前已被证明可促进REM睡眠的激素，可能有助于在暴露于乙醚后刺激REM睡眠。
