睡眠缺失改变小鼠前额叶皮层的突触和内在神经元特性。
Sleep loss alters synaptic and intrinsic neuronal properties in mouse prefrontal cortex.
机构信息
Program in Neuroscience, Washington State University, Pullman, WA 99164-6520, USA.
出版信息
Brain Res. 2011 Oct 28;1420:1-7. doi: 10.1016/j.brainres.2011.08.078. Epub 2011 Sep 7.
Abstract
Despite sleep-loss-induced cognitive deficits, little is known about the cellular adaptations that occur with sleep loss. We used brain slices obtained from mice that were sleep deprived for 8h to examine the electrophysiological effects of sleep deprivation (SD). We employed a modified pedestal (flowerpot) over water method for SD that eliminated rapid eye movement sleep and greatly reduced non-rapid eye movement sleep. In layer V/VI pyramidal cells of the medial prefrontal cortex, miniature excitatory post synaptic current amplitude was slightly reduced, miniature inhibitory post synaptic currents were unaffected, and intrinsic membrane excitability was increased after SD.
摘要
尽管睡眠剥夺会导致认知功能障碍，但人们对睡眠剥夺时发生的细胞适应性变化知之甚少。我们使用睡眠剥夺 8 小时的小鼠脑切片来研究睡眠剥夺的电生理效应。我们采用改良的水上平台法进行睡眠剥夺，消除了快速眼动睡眠，大大减少了非快速眼动睡眠。在中前额叶皮质的 V/VI 层锥体神经元中，微小兴奋性突触后电流幅度略有减小，微小抑制性突触后电流不受影响，而内在膜兴奋性在睡眠剥夺后增加。
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