Onn S P, West A R, Grace A A
Dept of Neurobiology and Anatomy, MCP Hahnemann University, Philadelphia, PA 19129, USA.
Trends Neurosci. 2000 Oct;23(10 Suppl):S48-56. doi: 10.1016/s1471-1931(00)00020-3.
The dopaminergic system exerts dynamic modulation of glutamatergic afferent drive that is dependent on the temporal pattern of the dopaminergic input and the subtypes of striatal neurons affected. The differences in feedforward inhibition between striatal neurons comprising the direct and indirect output pathway confer distinct response-pattern differences in their respective targets,supporting brief bursts of activity in Type-I neurons but attenuating repetitive activity in Type-II cells. This temporal patterning is further modulated by NO-mediated signaling, and by tonic and phasic dopamine-mediated stimulation, which exerts preferential actions on indirect and direct output neurons, respectively. As a result,the striatal network is forced into state-dependent patterns of activity that differentially regulate muscle tone and voluntary motor activity via distinct output projections from the striatum.
多巴胺能系统对谷氨酸能传入驱动进行动态调节，这种调节依赖于多巴胺能输入的时间模式以及受影响的纹状体神经元亚型。构成直接和间接输出通路的纹状体神经元之间前馈抑制的差异，在它们各自的靶标中产生了不同的反应模式差异，支持I型神经元的短暂活动爆发，但减弱II型细胞的重复活动。这种时间模式进一步受到一氧化氮介导的信号传导以及持续性和阶段性多巴胺介导的刺激的调节，它们分别对间接和直接输出神经元发挥优先作用。结果，纹状体网络被迫进入依赖状态的活动模式，通过纹状体不同的输出投射来差异性地调节肌张力和自主运动活动。
