Levy S B
Center for Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, MA 02111, USA.
Pediatr Infect Dis J. 2000 Oct;19(10 Suppl):S120-2. doi: 10.1097/00006454-200010001-00008.
More and more we are moving patients from hospitals to homes for continued treatment. Vancomycin and triclosan were used for 30 years before any resistance emerged, because their applications were strictly limited. Today, after greatly increased use, resistance to both antibiotics and antibacterials has appeared. Of importance there are genetic links between resistance to antibiotics and to antibacterials. Health professionals and the public need to be educated about the rational use of drugs that affect the microbial world. The Alliance for the Prudent Use of Antibiotics, an international organization established in 1981 with members in more than 100 countries, has adopted education as its prime mission. Via its web site (www.apua.org) and linked information on reservoirs of antibiotic resistance (ROAR) among nonpathogenic bacteria, it reaches both providers and consumers. The message is simple: bacteria are needed for our survival. The vast majority of bacteria perform important functions that are crucial for our lives. Prudent use of both antibiotics and antibacterials must be championed to achieve and maintain the balanced microbial environment in which we have entered and evolved.
越来越多的患者从医院转至家中接受持续治疗。万古霉素和三氯生在出现任何耐药性之前已使用了30年，因为它们的应用受到严格限制。如今，在使用量大幅增加后，对这两种抗生素和抗菌剂都出现了耐药性。重要的是，对抗生素和抗菌剂的耐药性之间存在基因联系。需要对卫生专业人员和公众进行关于合理使用影响微生物界药物的教育。审慎使用抗生素联盟是一个成立于1981年的国际组织，在100多个国家设有成员，已将教育作为其首要任务。通过其网站（www.apua.org）以及有关非致病性细菌中抗生素耐药性储存库（ROAR）的相关信息，它面向医疗服务提供者和消费者。传达的信息很简单：细菌是我们生存所必需的。绝大多数细菌执行着对我们生命至关重要的重要功能。必须倡导审慎使用抗生素和抗菌剂，以实现并维持我们所处及进化其中的平衡微生物环境。
