Serkedjieva J
Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Phytother Res. 2000 Nov;14(7):571-4. doi: 10.1002/1099-1573(200011)14:7<571::aid-ptr653>3.0.co;2-a.
The infusion prepared from flowers of Verbascum thapsiforme Schrad. (Scrophulariaceae) (FVI) reduced the infectious and haemagglutination yields of a range of influenza viruses in tissue cultures. Amantadine hydrochloride is an accepted and well studied selective inhibitor of influenza virus reproduction. The combined application of the plant preparation FVI and three amantadine derivatives resulted in a marked enhancement of the inhibitory effect of FVI on the reproduction of influenza virus A/chicken/Germany/27, strain Weybridge (H7N7) in cell cultures of chicken embryo fibroblasts. The antiviral activity was determined by the difference in the infectious titres of control and treated viruses. The combined effect was defined on the basis of infectious viral yields. The most pronounced enhancement was shown for the combination of FVI and adamantanamine glucuronide.
由毛蕊花（玄参科）花朵制备的浸液（FVI）降低了一系列流感病毒在组织培养中的感染性和血凝效价。盐酸金刚烷胺是一种公认且经过充分研究的流感病毒复制选择性抑制剂。植物制剂FVI与三种金刚烷胺衍生物联合应用，显著增强了FVI对鸡胚成纤维细胞培养物中甲型流感病毒A/鸡/德国/27（韦布里奇毒株，H7N7）复制的抑制作用。抗病毒活性通过对照病毒和处理后病毒感染滴度的差异来确定。联合效应基于感染性病毒产量来定义。FVI与金刚烷胺葡糖醛酸苷的组合显示出最显著的增强效果。
