Siegel S R, Brown F C, Castell D O, Johnson L F, Said S I
Dig Dis Sci. 1979 May;24(5):345-9. doi: 10.1007/BF01297119.
The effects of vasoactive intestinal polypeptide (VIP), glucagon, and secretin on lower esophageal sphincter pressure were investigated in awake baboons. The three hormones were compared with respect to effect on (1) resting lower esophageal sphincter pressure and (2) maximal stimulatory response to pentagastrin. VIP was shown to reduce resting and pentagastrin-stimulated lower esophageal sphincter pressure with significantly greater potency than either secretin or glucagon. For reduction of resting lower esophageal sphincter pressure, the potency ratio of VIP to secretin was 16:1 and of VIP to glucagon was 32:1 (P less than 0.05). For inhibition of pentagastrin-stimulated sphincter pressure, the potency ratio of VIP to secretin was 32:1 and of VIP to glucagon was 64:1 (P less than 0.02). This demonstration of significantly increased potency of VIP over known inhibitory hormones strengthens the suggestion that VIP may have a physiologic role in the control of lower esophageal sphincter function.
在清醒的狒狒身上研究了血管活性肠肽（VIP）、胰高血糖素和促胰液素对食管下括约肌压力的影响。比较了这三种激素在以下方面的作用：（1）对静息食管下括约肌压力的影响；（2）对五肽胃泌素的最大刺激反应。结果显示，VIP能降低静息和五肽胃泌素刺激的食管下括约肌压力，其效力显著高于促胰液素或胰高血糖素。对于降低静息食管下括约肌压力，VIP与促胰液素的效力比为16:1，VIP与胰高血糖素的效力比为32:1（P<0.05）。对于抑制五肽胃泌素刺激的括约肌压力，VIP与促胰液素的效力比为32:1，VIP与胰高血糖素的效力比为64:1（P<0.02）。VIP效力显著高于已知抑制激素的这一证明，强化了VIP可能在食管下括约肌功能控制中具有生理作用的观点。
