Yang X, Atalar E
Department of Radiology, Johns Hopkins University School of Medicine, Outpatient Center Rm 4243, 601 N Caroline St, Baltimore MD 21287-0845, USA.
Radiology. 2000 Nov;217(2):501-6. doi: 10.1148/radiology.217.2.r00oc17501.
To develop a technique for intravascular magnetic resonance (MR)-guided balloon angioplasty with use of an MR imaging guide wire.
An MR imaging guide wire (0.6-mm loopless antenna) that could be placed within a balloon catheter was manufactured. The guide wire was expected to function as either an MR receiver probe in real-time MR imaging or a guide wire for use with interventional devices. Laparotomy was performed in eight rabbits, and a dilatable stenosis was created at the upper abdominal aorta. Balloon angioplasty, validated at pre- and postoperative MR aortography with renal contrast enhancement was performed by using a 1.5-T MR unit with a fast spoiled gradient-echo pulse sequence, short repetition and echo times, and a rate of three frames per second.
During MR tracking, the entire length of the MR imaging guide wire was always visible as a band of high signal intensity. In all cases, the MR imaging guide wires were passed through the aortic stenoses dilated by means of balloon inflation. Before balloon angioplasty, flow in the aorta distal to the stenosis was decreased, which caused mild contrast enhancement in each kidney. After balloon angioplasty, distal flow was restored, resulting in substantial renal enhancement.
The MR imaging guide wire is a potential tool for use in endovascular interventional MR imaging.
开发一种利用磁共振成像导丝进行血管内磁共振（MR）引导下球囊血管成形术的技术。
制造了一种可置于球囊导管内的磁共振成像导丝（0.6毫米无环天线）。该导丝预期可在实时磁共振成像中用作MR接收探头，或用作与介入装置配合使用的导丝。对8只兔子进行剖腹手术，并在上腹主动脉处制造可扩张狭窄。通过使用具有快速扰相梯度回波脉冲序列、短重复时间和回波时间以及每秒三帧速率的1.5-T MR单元，在术前和术后肾对比增强的磁共振主动脉造影中验证球囊血管成形术。
在MR跟踪过程中，磁共振成像导丝的全长始终可见为一条高信号强度带。在所有病例中，磁共振成像导丝均穿过通过球囊扩张的主动脉狭窄处。在球囊血管成形术之前，狭窄远端主动脉内的血流减少，导致每个肾脏出现轻度对比增强。球囊血管成形术后，远端血流恢复，导致肾脏显著增强。
磁共振成像导丝是血管内介入性磁共振成像中一种有潜力的工具。
