Yang X, Bolster B D, Kraitchman D L, Atalar E
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287-0845, USA.
J Vasc Interv Radiol. 1998 Nov-Dec;9(6):953-9. doi: 10.1016/s1051-0443(98)70429-4.
To develop a new method for monitoring balloon angioplasty by using an intravascular magnetic resonance (MR) imaging technique.
Nine New Zealand White rabbits were used: seven for technique refinement, including surgery, device insertion, stenosis creation, and MR protocol development; and two for the final MR imaging of the balloon angioplasty. The in vivo experimental method involved insertion of a catheter antenna and a balloon catheter, via femoral arteriotomies bilaterally, into the target site of the upper abdominal aorta, where a stenosis was artificially created by binding a plastic cable tie. Then, the entire process of the dilation of the stenosis with balloon inflation was monitored under MR fluoroscopy.
Catheter insertions were successful, and a 5-mm-long stenosis of the aorta was produced in all nine rabbits. Eight complete balloon angioplasty procedures were satisfactorily monitored and recorded, showing clearly the stenosis of the aorta at the beginning of the procedure, the dilation of the stenosis during the balloon inflation, and the complete opening of the stenosis after balloon dilation.
Preliminary results of in vivo balloon angioplasty monitored with intravascular MR imaging are presented. MR fluoroscopy, based on the intravascular MR imaging technique, may represent a potential alternative to x-ray fluoroscopy for guiding interventional treatment of cardiovascular diseases.
开发一种利用血管内磁共振（MR）成像技术监测球囊血管成形术的新方法。
使用9只新西兰白兔：7只用于技术完善，包括手术、装置插入、狭窄创建和MR方案制定；2只用于球囊血管成形术的最终MR成像。体内实验方法包括通过双侧股动脉切开术将导管天线和球囊导管插入上腹部主动脉的目标部位，在此通过绑扎塑料束带人为制造狭窄。然后，在MR透视下监测球囊充气扩张狭窄的整个过程。
导管插入成功，所有9只兔子均产生了5毫米长的主动脉狭窄。8次完整的球囊血管成形术过程得到了满意的监测和记录，清楚显示了手术开始时主动脉的狭窄、球囊充气过程中狭窄的扩张以及球囊扩张后狭窄的完全开通。
展示了血管内MR成像监测体内球囊血管成形术的初步结果。基于血管内MR成像技术的MR透视可能成为用于指导心血管疾病介入治疗的X线透视的一种潜在替代方法。
