Grosse G, Mishra S K, Staib F
Zentralbl Bakteriol Orig A. 1975 Sep;233(1):106-22.
In the present communication the previously described cultural findings about the selective involvement of the central nervous system by C. neoformans, strain W 2/A 94, have been supplemented by the results of histopathological investigations. Attention has been paid to the organ specific tissue reaction during the course of infection, with special reference to the involvement of the brain. In agreement with former observations concerning the cryptococcoma in the muscle-tissue, the cryptococcal foci in the brain also showed the phenomenon of vascularisation. The results have been compared with those of the C. neoformans, strain W 71/A 117 which does not allow such a prolonged selective involvement of the central nervous system due to its high virulence for the white mice. These observations impressively demonstrate the significance of simultaneous microbiological and histopathological examinations for the detection of infections caused by such facultative pathogens.
在本报告中，关于新型隐球菌W 2/A 94菌株对中枢神经系统的选择性侵犯，先前描述的培养结果已得到组织病理学研究结果的补充。已关注感染过程中器官特异性组织反应，尤其关注脑部受累情况。与先前关于肌肉组织中隐球菌瘤的观察结果一致，脑内的隐球菌病灶也显示出血管形成现象。已将这些结果与新型隐球菌W 71/A 117菌株的结果进行比较，该菌株因其对白鼠的高毒力，不允许中枢神经系统出现如此长时间的选择性侵犯。这些观察结果令人印象深刻地证明了同时进行微生物学和组织病理学检查对于检测此类兼性病原体引起的感染的重要性。
