Staib F, Mishra S K, Grosse G, Abel T
Zentralbl Bakteriol Orig A. 1977;237(2-3):378-94.
During the previous studies, we could demonstrate that there are strains of Cryptococcus neoformans which after intraperitoneal inoculation, are capble of surviving only in the brain of mice without causing any apparent clinical symptom; only in about 4% of the animals the fatal involvement of the CNS occurred. The present investigations suggest that the selective involvement of eye, i.e., formation of intraocular cryptococcoma, with subsequent blindness is also possible under similar experimental conditions. It was observed that a short-lived uremia caused by intramuscular injection of 0.2 ml glycerine could enhance the rate of the selective involvement of the CNS including the eye. The uremia was controlled by the auxanographic method using STAIB's technique of serum-residual-nitrogen-auxanogram and employing the strain used for infecting the mice. These animal experiments are discussed in connection with a clinical case of intra-ocular cryptococcosis in which the only known basic disease was uremia of unknown orgin. The spontaneously healing cryptococcosis detected in this case after the treatment of uremia, has been discussed. Cases of ocular cryptococcosis described in the world literature have been also briefly discussed inconnection with our results. These microbiological observations will be supplemented by the histopathological findings to be published separately.
在先前的研究中，我们能够证明，有一些新型隐球菌菌株在腹腔接种后，仅能在小鼠脑内存活而不引起任何明显的临床症状；只有约4%的动物会发生致命的中枢神经系统感染。目前的研究表明，在类似的实验条件下，眼睛的选择性感染，即眼内隐球菌瘤的形成以及随后的失明也是可能的。据观察，肌肉注射0.2毫升甘油引起的短期尿毒症可提高包括眼睛在内的中枢神经系统选择性感染的发生率。通过使用STAIB血清残余氮生长谱技术并采用用于感染小鼠的菌株，用生长谱法控制尿毒症。结合一例眼内隐球菌病的临床病例讨论了这些动物实验，该病例中唯一已知的基础疾病是病因不明的尿毒症。讨论了该病例在尿毒症治疗后检测到的自发愈合的隐球菌病。世界文献中描述的眼内隐球菌病病例也结合我们的结果进行了简要讨论。这些微生物学观察结果将由另行发表的组织病理学发现加以补充。
